PHARMACODYNAMICS OF MIVACURIUM IN CHILDREN, USING A COMPUTER-CONTROLLED INFUSION

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منابع مشابه

Pharmacodynamics of mivacurium in infants.

A computerized infusion system was used to determine mivacurium infusion requirements to maintain 95% and 50% neuromuscular block in 15 infants less than 1 yr of age. Neuromuscular block was measured by adductor pollicis EMG and anaesthesia maintained with 66% nitrous oxide in oxygen and alfentanil 50-100 micrograms kg-1 h-1. Neuromuscular block was produced by repeated bolus doses of mivacuriu...

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The pharmacodynamics and pharmacokinetics of mivacurium in children.

BACKGROUND In children, onset time and duration of action of mivacurium are shorter than in adults. Some suggest that this is due to differences in plasma cholinesterase (pChe), whereas others indicate that there is no difference. The purpose of this study was to evaluate the pharmacodynamics and pharmacokinetics of mivacurium in phenotypically normal children aged 3-6 and 10-14 years old, resp...

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Postoperative recurrent paralysis in an infant after mivacurium infusion.

1 Webster AC, Morley-Foster PK, Dain S, et al. Anaesthesia for adenotonsillectomy: a comparison between tracheal intubation and the armoured laryngeal mask airway. Can J Anaesth 1993; 40:1171-7. 2 Taylor MB, Whitwam JG. The accuracy of pulse oximeters. A comparative clinical evaluation of five pulse oximeters. Anaesthesia 1988; 43: 229-32. 3 Patel RI, Hannallah RS, Norden J, Casey WE Verghese S...

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[Comparison of recovery time of bolus and continuous infusion mivacurium.].

BACKGROUND AND OBJECTIVES Mivacurium is a short-acting neuromuscular blocker (NMB), with total duration not exceeding 24 minutes. Early publications have reported no significant differences in recovery time, regardless of the route administration. However, clinical experience points out to longer recovery times when the drug is administered in continuous infusion. This study aimed at comparing ...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1993

ISSN: 0007-0912

DOI: 10.1093/bja/71.2.232